The Mexico City Prospective Study was established between 1998 and 2004, when 100,000 women and 50,000 men from Mexico City were surveyed in their homes;on a range of questions about their lifestyle, socio-demographic characteristics, medications and disease history. A range of of physical measurements were taken (anthropometric, blood pressure) anda blood sample provided. Participants are tracked for cause-specific mortality (20,000 dead by January 2016) and a resurvey of 10,000 survivors in ongoing. By relating participants' characteristics at recruitment to death over the following decades, this study is now investigating the main causes of premature death in Mexico.
By age 60, nearly half of women and one-third of men were obese and more than 1-in-5 had a confirmed diagnosis of diabetes. Glycaemic control in those with previously-diagnosed diabetes was poor (one third had HbA1c;10%) and, over the next 12 years, those with such a diagnosis had;four times;the overall death rate at ages 35-74 compared with people without diabetes, with the biggest excess risks of death from kidney disease, vascular disease, infection and acute diabetic crises. Overall, the excess mortality among people with diabetes accounted for at least;one-third of all deaths; between the ages 35-74 years, which is twice what previous studies had suggested.
Sample size at recruitment: 150,000 with stored blood. Estimated current sample size: By 1.1.2016, about 20,000 of the original 150,000 participants had died.
Unit of analysis
Coyoacan and Iztapalapa, Mexico City
Unit of analysis
Producers and Sponsors
National Autonomous University of Mexico
Clinical Trial Service Unit
Mexican Ministry of Health
Mexican National Council of Science and Technology